ABSTRACT
The aqueous extract (AE) and isolated fraction (ppt-3) of Cuphea carthagenensis (Jacq.) J. F. Macbr (sete-sangrias) were tested using models of nociception and inflammation in mice. Oral administration (p.o.) of the AE (10 to 100 mg/kg) and fraction ppt-3 (0.1 to 10 mg/kg) reduced the acetic acid-induced writhing in mice by 40 to 50 percent and by 46 to 70 percent of control, respectively. At the same doses AE and ppt-3 did not affect the tail flick response. Fraction ppt-3 also reduced the carrageenininduced paw edema, but at a dose 1000 times higher than that inducing antinociception. The results indicated the presence in the plant of antinociceptive constituents devoid of antiinflammatory activity, with actions apparently mediated by non-opioid mechanisms.
ABSTRACT
La xantomatosis plana difusa es una enfermedad rara, dentro del grupo de las xantomatosis. Se presenta con infiltración y cambio de coloración de la piel; puede asociarse a enfermedades sistémicas, las que marcan su pronóstico. Se presenta un caso de xantomatosis plana difusa asociada a gammapatía monoclonal
Subject(s)
Humans , Female , Middle Aged , Xanthomatosis/classification , Hyperlipidemias/complications , Monoclonal Gammopathy of Undetermined Significance/complications , Paraproteinemias/complications , Prognosis , Xanthomatosis/complications , Xanthomatosis/physiopathologyABSTRACT
Various concentrations of chilli extract were tested in 2 stages on the growth of a human buccal mucosa fibroblast cell line. Firstly, concentrations of 25, 75, 150 and 300 micrograms/ml were tested on the cell line for 6 days followed by a repeat which included concentrations of 400 and 500 micrograms/ml. In the latter, cell growth was monitored for 18 days. From day 3 (72 hr) suppression of cell growth was evident with concentrations 300-500 micrograms/ml. Total cell death occurred at 16 days with 300 micrograms/ml and at 6 days with 400-500 micrograms/ml. With the lower concentrations, 25-150 micrograms/ml, the daily counts were lower than the control but the difference was not statistically significant. Growth continued unabated. It is therefore concluded that cytopathic effect of chilli extract to fibroblasts is concentration dependent.